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Clinical Trial
. 1984 Jun;69(6):428-30.
doi: 10.1111/j.1600-0404.1984.tb07826.x.

Clonazepam and vibration in restless legs syndrome

P Montagna, L Sassoli de Bianchi, M Zucconi, F Cirignotta, E Lugaresi
Clinical Trial

Clonazepam and vibration in restless legs syndrome

P Montagna et al. Acta Neurol Scand. 1984 Jun.

Abstract

There have been no controlled therapeutic trials in Restless Legs Syndrome (RLS). In 6 patients with RLS, a randomized double-blind cross-over trial vs placebo showed a significant efficacy of clonazepam in improving subjective quality of sleep and leg dysaesthesia. Vibratory stimulation of the leg showed a less pronounced and non-significant effect. Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation.

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