Bordetella pertussis whole cell vaccines--efficacy and toxicity

Abstract

The literature concerning efficacy and side effects of pertussis vaccines is reviewed. With few exceptions, most vaccines induce a protective immunity lasting for 2 to 5 years. The large-scale use of pertussis vaccines has markedly contributed to the decrease in pertussis morbidity in small children but in some countries the incidence has increased in older children. Not even countries with immunisation rates of 90-95% have managed to eradicate pertussis or prevent disease in infants below the age of immunisation. The pertussis-associated mortality is currently very low in the industrialised countries and no differences can be discerned when countries with high, low and zero immunisation rates are compared. Local and benign systemic reactions are commonly seen after immunisation. The vaccines also sometimes cause convulsions, a shock-like state and, rarely, serious neurological reactions.