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. 1978 Mar;38(3):339-44.
doi: 10.1111/j.1365-2141.1978.tb01052.x.

Fetal haemoglobin in early malignant osteopetrosis

G Schilirò, S Musumeci, G Pizzarelli, A Russo, M Marinucci, L Tentori, G Russo

Fetal haemoglobin in early malignant osteopetrosis

G Schilirò et al. Br J Haematol. 1978 Mar.

Abstract

The characteristics of the fetal haemoglobin (HbF) in two children with osteopetrosis and high levels of HbF have been studied. The structural analysis of the gamma chains demonstrated a fetal Ggamma/Agamma ratio. HbF was distributed inside only 30% of the peripheral red blood cells. In vitro globin chain synthesis studies showed that there was balanced globin chain production, despite the increased level of HbF.

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