Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1984 Jun;142(2):147-50.
doi: 10.1007/BF00445602.

Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency

U Wendel, H J Bremer
Case Reports

Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency

U Wendel et al. Eur J Pediatr. 1984 Jun.

Abstract

In a 3-year-old mentally retarded girl with homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency among different therapeutic approaches only treatment with betaine (15-20 g/day) resulted in a satisfactory biochemical response. Betaine improved homocysteine remethylation and thus lowered plasma homocystine to trace amounts and normalized the previously very low plasma methionine concentration. This biochemical response was associated with a clinical improvement although she remained mentally retarded.

PubMed Disclaimer

References

    1. J Pediatr. 1983 Jun;102(6):938-40 - PubMed
    1. N Engl J Med. 1975 Mar 6;292(10):491-6 - PubMed
    1. Clin Chim Acta. 1967 Mar;15(3):409-20 - PubMed
    1. J Pediatr. 1965 Jul;67:58-68 - PubMed
    1. Pediatr Res. 1976 Jun;10(6):598-609 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources