Effects of neoglycoproteins on penetration of Plasmodium falciparum merozoites into erythrocytes in vitro
- PMID: 6381683
Item in Clipboard
Effects of neoglycoproteins on penetration of Plasmodium falciparum merozoites into erythrocytes in vitro
J Parasitol.
1984 Apr.
Abstract
Sugars conjugated to bovine serum albumin (neoglycoproteins) were tested for their ability to inhibit Plasmodium falciparum merozoite invasion of red blood cells in an in vitro inhibition assay. The inhibitory effects of the neoglycoproteins on merozoite invasion of erythrocytes were determined by assessing 3H-hypoxanthine incorporation into the cultures. The only neoglycoprotein that caused significant inhibition N-acetyl-glucosamine-bovine serum albumin. A comparison of the inhibitory effects of N-acetyl-glucosamine and N-acetyl-glucosamine-bovine serum albumin showed that N-acetyl-glucosamine-bovine serum albumin was 84 fold more effective than the free sugar in causing 50% inhibition of 3H-hypoxanthine incorporation.
Similar articles
-
Stage-dependent toxicity of N-acetyl-glucosamine to Plasmodium falciparum.J Protozool. 1985 Feb;32(1):91-5. doi: 10.1111/j.1550-7408.1985.tb03020.x. J Protozool. 1985. PMID: 3886901
-
Toxicity of "hydrophobic groupings" and the role of carbohydrates in Plasmodium falciparum infection.Behring Inst Mitt. 1986 Jun;(80):64-73. Behring Inst Mitt. 1986. PMID: 3530236
-
Factors influencing invasion of erythrocytes by Plasmodium falciparum parasites: the effects of an N-acetyl glucosamine neoglycoprotein and an anti-glycophorin A antibody.Am J Trop Med Hyg. 1986 Sep;35(5):898-905. doi: 10.4269/ajtmh.1986.35.898. Am J Trop Med Hyg. 1986. PMID: 3532846
-
Studies on the biochemical basis of the interaction of the merozoites of Plasmodium falciparum and the human red cell.Trans R Soc Trop Med Hyg. 1985;79(5):591-7. doi: 10.1016/0035-9203(85)90164-6. Trans R Soc Trop Med Hyg. 1985. PMID: 3913066 Review.
-
Erythrocyte invasion by malaria (Plasmodium falciparum) merozoites: recent advances in the evaluation of receptor sites.Behring Inst Mitt. 1984 Nov;(76):121-41. Behring Inst Mitt. 1984. PMID: 6395849 Review.
Cited by
-
Role of the carbohydrate domains of glycophorins as erythrocyte receptors for invasion by Plasmodium falciparum merozoites.Infect Immun. 1985 Jan;47(1):201-10. doi: 10.1128/iai.47.1.201-210.1985. Infect Immun. 1985. PMID: 3880722 Free PMC article.
-
Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins.Proc Natl Acad Sci U S A. 1990 Sep;87(18):7339-43. doi: 10.1073/pnas.87.18.7339. Proc Natl Acad Sci U S A. 1990. PMID: 2205856 Free PMC article.
-
Specific binding of neoglycoproteins to Toxoplasma gondii tachyzoites.Infect Immun. 1991 Dec;59(12):4670-3. doi: 10.1128/iai.59.12.4670-4673.1991. Infect Immun. 1991. PMID: 1937826 Free PMC article.