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. 1978 Mar;62(3):359-61.
doi: 10.1111/j.1476-5381.1978.tb08468.x.

Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands

S Ito, Y Nakazato, A Ohga

Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands

S Ito et al. Br J Pharmacol. 1978 Mar.

Abstract

Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium (1.83 mM) and atropine (28.8 micrometer). The response to veratridine was abolished by removal of either Na+ or Ca2+ from perfusion media and by the addition of tetrodotoxin (0.1 micrometer). It is suggested that the response to veratridine may be due to an increase in the tetrodotoxin-sensitive Na+ permeability of chromaffin cell membranes.

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References

    1. J Physiol. 1963 Jul;167(2):288-310 - PubMed
    1. J Pharmacol Exp Ther. 1962 Dec;138:360-75 - PubMed
    1. J Physiol. 1961 Nov;159:40-57 - PubMed
    1. J Physiol. 1976 Dec;263(3):417-39 - PubMed
    1. J Physiol. 1976 Nov;262(3):743-53 - PubMed

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