Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Mar;62(3):362-3.
doi: 10.1111/j.1476-5381.1978.tb08469.x.

Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats

R E Buckingham, T C Hamilton, D Robson

Diminishing hypotensive effect of increasing doses of pindolol in DOCA/saline hypertensive rats

R E Buckingham et al. Br J Pharmacol. 1978 Mar.

Abstract

In DOCA-saline hypertensive rats, pindolol (4, 20 or 50 mg/kg orally) produced a hypotensive effect which was inversely related to dose. Following adrenal demedullation, a hypotensive response to the highest dose of pindolol was unmasked and the magnitude of the responses to lower doses was increased. The results suggest that adrenal catecholamines moderate the hypotensive effects of high doses of pindolol.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Br J Pharmacol. 1977 Jul;60(3):461-9 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmakol. 1970;265(5):387-96 - PubMed
    1. Experientia. 1969 Aug 15;25(8):802-3 - PubMed
    1. J Pharm Pharmacol. 1976 May;28(5):459-61 - PubMed
    1. Pharmacology. 1972;8(4):344-52 - PubMed

LinkOut - more resources