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Case Reports
. 1978 Apr;65(4):234-6.
doi: 10.1002/bjs.1800650406.

Cure of intractable watery diarrhoea by excision of a vipoma

I M Modlin, S R Bloom, A Barnes, R B Welbourn
Case Reports

Cure of intractable watery diarrhoea by excision of a vipoma

I M Modlin et al. Br J Surg. 1978 Apr.

Abstract

A 56-year-old man suffered unexplained watery diarrhoea for 5 years which ultimately produced quadraparesis due to serve potassium depletion. All investigations were negative until demonstration of elevated plasma vasoactive intestinal peptide (VIP) indicated the presence of a vipoma. Removal of the VIP-producing tumour tissue--an adrenal ganglioneuroma--resulted in complete cure. Plasma VIP measurement is thus a valuable diagnostic screen in such cases and can be used to predict prognosis and to guide further therapy.

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