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. 1984 Sep;33(5):767-71.
doi: 10.4269/ajtmh.1984.33.767.

Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects

T M Cosgriff, E F Boudreau, C L Pamplin 3rd, J D Berman, M J Shmuklarsky, C J Canfield

Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects

T M Cosgriff et al. Am J Trop Med Hyg. 1984 Sep.

Abstract

WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.

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