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. 1984 Sep 17;123(2):482-8.
doi: 10.1016/0006-291x(84)90256-0.

The proteolytic activity of human prostate-specific antigen

Y Ban, M C Wang, K W Watt, R Loor, T M Chu

The proteolytic activity of human prostate-specific antigen

Y Ban et al. Biochem Biophys Res Commun. .

Abstract

Human prostate-specific antigen has been found to exhibit a mild activity of protease at neutral pH. This finding is based on two observations: a proteolytic activity was always associated with the antigen fractions during purification, and the proteolytic activity and the antigen were precipitated with specific antibody to the antigen. In comparison with physico-chemical and catalytic properties of known proteases, human prostate-specific antigen is a distinct neutral protease.

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