Neonatal tetanus in the world today
Abstract
Neonatal tetanus is an important cause of avoidable morbidity and mortality. In the past this disease was overlooked by the health services of many developing countries, but recently the extent and magnitude of neonatal tetanus has become clearer and shown that it is a very serious health problem in the developing countries. The results of community-based surveys show that neonatal tetanus mortality rates range from less than 5 to more than 60 per 1000 live births; these deaths represent between 23% and 72% of all neonatal deaths. The results so far suggest that this disease claims the lives of over half a million new-born children every year. All forms of tetanus, and especially neonatal tetanus, remain substantially under-reported in many countries, and routine reporting systems identify only about 2-5% of the estimated number of tetanus cases (based on the results of community surveys). More reliable and accurate estimates of the incidence and mortality from tetanus are therefore required.The elimination of neonatal tetanus is an essential and attainable goal. It may be achieved by combining two approaches: (1) increasing the immunization coverage of women of child-bearing age, and especially pregnant women, with tetanus toxoid, and (2) improving maternity care, with particular emphasis on increasing the proportions of deliveries that are attended by trained persons.Neonatal tetanus mortality should serve as an index of the quality and the extent of utilization of the maternal health services, of the impact of immunization programmes, and of the progress being made in achieving the WHO goal of "Health for All by the Year 2000".The elimination of neonatal tetanus calls for a full commitment by governments and by other bodies, public and private, with a responsibility for the care of women and children. The occurrence of even a single case of neonatal tetanus is witness to failures in the health system, for prevention is possible through the actions of trained health staff in contact with the mother.
Similar articles
-
Progress towards the global elimination of neonatal tetanus.World Health Stat Q. 1992;45(2-3):248-56. World Health Stat Q. 1992. PMID: 1462659
-
Control of neonatal tetanus in India.Indian Pediatr. 1984 Jul;21(7):515-9. Indian Pediatr. 1984. PMID: 6519778
-
Epidemiological factors associated with neonatal tetanus mortality: observations from a cluster survey in Nigeria.East Afr Med J. 1993 Jul;70(7):434-7. East Afr Med J. 1993. PMID: 8293702
-
Neonatal tetanus elimination in Pakistan: progress and challenges.Int J Infect Dis. 2012 Dec;16(12):e833-42. doi: 10.1016/j.ijid.2012.07.015. Epub 2012 Aug 30. Int J Infect Dis. 2012. PMID: 22940280 Review.
-
Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence.Pediatrics. 2005 Feb;115(2 Suppl):519-617. doi: 10.1542/peds.2004-1441. Pediatrics. 2005. PMID: 15866863 Review.
Cited by
-
Surveillance for the Expanded Programme on Immunization.Bull World Health Organ. 1993;71(5):633-9. Bull World Health Organ. 1993. PMID: 8261567 Free PMC article.
-
Tetanus in Ethiopia: unveiling the blight of an entirely vaccine-preventable disease.Curr Neurol Neurosci Rep. 2012 Dec;12(6):655-65. doi: 10.1007/s11910-012-0314-3. Curr Neurol Neurosci Rep. 2012. PMID: 22996275 Review.
-
Recombinant human antibody fragment against tetanus toxoid produced by phage display.Eur J Microbiol Immunol (Bp). 2014 Mar;4(1):45-55. doi: 10.1556/EuJMI.4.2014.1.4. Epub 2014 Mar 14. Eur J Microbiol Immunol (Bp). 2014. PMID: 24678405 Free PMC article.
-
Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C.Infect Immun. 1999 Aug;67(8):3810-5. doi: 10.1128/IAI.67.8.3810-3815.1999. Infect Immun. 1999. PMID: 10417142 Free PMC article.
-
Neonatal morbidity and mortality in Nigeria.Indian J Pediatr. 1998 May-Jun;65(3):441-9. doi: 10.1007/BF02761140. Indian J Pediatr. 1998. PMID: 10771996
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous