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. 1984 Sep;27(3):416-8.
doi: 10.1007/BF00304861.

Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats

U Helmchen, W E Schmidt, E G Siegel, W Creutzfeldt

Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats

U Helmchen et al. Diabetologia. 1984 Sep.

Abstract

Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.

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