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Comparative Study
. 1984;312(5996):724-9.
doi: 10.1038/312724a0.

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

D Pennica, G E Nedwin, J S Hayflick, P H Seeburg, R Derynck, M A Palladino, W J Kohr, B B Aggarwal, D V Goeddel
Comparative Study

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

D Pennica et al. Nature. 1984.

Abstract

Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.

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