Neurological disorders of the myenteric plexus: a review

Abstract

The myenteric plexus is the neuronal complex that regulates the motility of the gut; a brief review of its pathology is presented in this paper as well as a tentative etiopathogenetic classification. Disorders of gut innervation include congenital (e.g. Hirschsprung's disease) or acquired diseases; the latter can be idiopathic or related to a more general pathological involvement of the whole organism as in the case of bacterial toxins, diabetes mellitus, Riley-Day disease and primary orthostatic hypotension. In view of the fundamental similarity of the myenteric plexus to the central nervous system, the study of this organ can be useful both for diagnosis of degenerative diseases of the central nervous system (i.e. via rectal biopsy) and for gaining a better etiopathogenetic insight into peripheral and central nervous system disease.