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. 1978 Apr 15;34(4):488-90.
doi: 10.1007/BF01935944.

The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells

T Akasu, Y Ohta, K Koketsu

The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells

T Akasu et al. Experientia. .

Abstract

Electrogenic Na+ pump currents during K+-activated hyperpolarizations of bullfrog atrium muscle fibres are increased by adrenaline. The log dose-response relation between these currents and activating K+ concentrations is expressed by a sigmoidal curve, which is shifted in parallel to the left by adrenaline. It is suggested that adrenaline increases the rate of Na+ extrusion without increasing the Na/K coupling ratio and total number of pumping sites.

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