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. 1983 Jan 22;286(6361):253-5.
doi: 10.1136/bmj.286.6361.253.

HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs

C Johnston, D A Pyke, A G Cudworth, E Wolf

HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs

C Johnston et al. Br Med J (Clin Res Ed). .

Abstract

A total of 106 pairs of identical twins, of whom 56 were concordant and 50 discordant for insulin-dependent diabetes, were typed for HLA-DR. In both the concordant and discordant groups there was a high prevalence of the antigens DR3 and DR4, a low prevalence of DR5 and DR7, and a virtual absence of DR2. The heterozygous phenotype DR3,DR4 was more prevalent in concordant than discordant pairs. This was therefore the first demonstration of a genetic difference between concordant and discordant identical twin pairs. These findings suggest that possession of both DR3 and DR4 antigens confers a greater genetic predisposition to insulin-dependent diabetes than does the possession of either antigen alone.

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