Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jan 10;151(1):22-6.
doi: 10.1016/0014-5793(83)80334-2.

Structure determination of the major asparagine-linked sugar chain of human factor VIII--von Willebrand factor

P Debeire, J Montreuil, B Samor, C Mazurier, M Goudemand, H van Halbeek, J F Vliegenthart
Free article

Structure determination of the major asparagine-linked sugar chain of human factor VIII--von Willebrand factor

P Debeire et al. FEBS Lett. .
Free article

Abstract

N-glycosidically-linked glycans released by hydrazinolysis of human factor VIII/von Willebrand factor (FVIII/vWf) were separated by high-voltage electrophoresis. Five fractions were obtained, one of them representing 60% of the total amount of the N-glycosidically-linked glycans of FVIII/vWf. On the basis of the carbohydrate composition, methylation analysis and 500 MHz 1H-NMR spectroscopy, we describe the primary structure of this major glycan which is of the monosialylated and monofucosylated biantennary N-acetyllactosaminic type.

PubMed Disclaimer

Publication types

LinkOut - more resources