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. 1983 Feb;45(2):546-9.
doi: 10.1128/aem.45.2.546-549.1983.

Effects of temperature and relative humidity on biological indicators used for ethylene oxide sterilization

G S Oxborrow, A M Placencia, J W Danielson

Effects of temperature and relative humidity on biological indicators used for ethylene oxide sterilization

G S Oxborrow et al. Appl Environ Microbiol. 1983 Feb.

Abstract

A study was made to determine the effects of temperature and moisture on the D-value of a common biological indicator. Relative humidity (RH) was varied between 10 and 70% in increments of 10%, and temperature was varied between 30 and 70 degrees C in increments of 10 degrees C. Temperature was found to have a pronounced effect on the D-value. At 60% RH, the D-value varied from 15.0 min at 30 degrees C to 1.1 min at 70 degrees C. When RH was plotted against the average D-value at the various temperatures, the temperature curves at or above 50 degrees C were more erratic and the RH had a significant effect. The study showed that temperature and RH must be controlled if biological indicators are to be properly calibrated for use in ethylene oxide sterilization.

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