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. 1983 Mar;302(5906):305-10.
doi: 10.1038/302305a0.

Structure and expression of a cloned cDNA for human interleukin-2

T Taniguchi, H Matsui, T Fujita, C Takaoka, N Kashima, R Yoshimoto, J Hamuro

Structure and expression of a cloned cDNA for human interleukin-2

T Taniguchi et al. Nature. 1983 Mar.

Abstract

A cDNA coding for human interleukin-2 (IL-2) has been cloned from a cDNA library prepared from partially purified IL-2 mRNA. The DNA sequence codes for a polypeptide which consists of 153 amino acids including a putative signal sequence. A biologically active polypeptide, characteristic of human IL-2, was produced when the cDNA was fused to a simian virus 40 promoter sequence and used to transfect cultured monkey COS cells.

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