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. 1983 Apr 21;302(5910):676-81.
doi: 10.1038/302676a0.

Three-dimensional architecture of a polytene nucleus

D A Agard, J W Sedat

Three-dimensional architecture of a polytene nucleus

D A Agard et al. Nature. .

Abstract

The three-dimensional chromosome topography in an intact nucleus has been determined using fluorescently stained Drosophila polytene chromosomes, optical fluorescence microscopy and newly developed, generally applicable, cellular image reconstruction techniques. The folding pattern is a complex mixture of parallel chromosomal segments and intertwined coils and shows extensive interaction of the chromosomes with the nuclear envelope.

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