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. 1983 May 13;220(4598):680-6.
doi: 10.1126/science.6403986.

Bone cell differentiation and growth factors

M R Urist, R J DeLange, G A Finerman

Bone cell differentiation and growth factors

M R Urist et al. Science. .

Abstract

Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.

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