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. 1983 Mar 16;111(2):602-10.
doi: 10.1016/0006-291x(83)90349-2.

Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings

A Le Pape, N Gutman, J D Guitton, Y Legrand, J P Muh

Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings

A Le Pape et al. Biochem Biophys Res Commun. .

Abstract

Pepsin extracted collagen and an acid soluble glycoprotein were purified from placentas of normal and diabetic human beings. Diabetic samples exhibit a significant increase in ketoamine-linked glucose whereas both amino acid and carbohydrate composition were unaffected. This excess non enzymatic condensation of glucose on free amino-groups was found to increase platelet aggregating potency of these proteins independently of any modification in fiber morphology.

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