doi: 10.1016/0306-3623(83)90002-2.
Harding-passey mouse-melanoma tyrosinase inactivation by reaction products and activation by L-epinephrine
- PMID: 6404691
- DOI: 10.1016/0306-3623(83)90002-2
Item in Clipboard
Harding-passey mouse-melanoma tyrosinase inactivation by reaction products and activation by L-epinephrine
Gen Pharmacol.
1983.
Abstract
1. Harding-Passey mouse-melanoma tyrosinase (EC 1.14.18.1) is inhibited during L-3,4-dihydroxyphenylalanine oxidation by reaction products. L-3,4-dihydroxyphenyl 3-[14C]alanine oxidation products bind to the enzyme, as demonstrated by gel electrophoresis and radioactivity measurements. 2. The enzyme interacts with indoles and oxidizes dopamine and norepinephrine. 3. L-epinephrine activates tyrosinase at non hormonal concentrations and bovine serum albumin protects the enzyme from auto-inhibition. 4. The inhibition of the Harding-Passey mouse-melanoma tyrosinase, during substrate oxidation, is very similar to that of mushroom enzyme.
Similar articles
-
Inhibition of tyrosinase by indole compounds and reaction products. Protection by albumin.Biochim Biophys Acta. 1979 Jul 4;585(3):398-404. doi: 10.1016/0304-4165(79)90084-9. Biochim Biophys Acta. 1979. PMID: 114228
-
Inactivation of tyrosinase by dopa.J Invest Dermatol. 1980 Nov;75(5):379-82. doi: 10.1111/1523-1747.ep12523615. J Invest Dermatol. 1980. PMID: 6776205
-
5,6-Dihydroxyindole oxidation by mammalian, mushroom and amphibian tyrosinase preparations.Biochim Biophys Acta. 1985 Aug 16;841(2):159-65. doi: 10.1016/0304-4165(85)90017-0. Biochim Biophys Acta. 1985. PMID: 3926006
-
Inactivation mechanism of tyrosinase in mouse melanoma.J Dermatol. 1977 Dec;4(6):245-9. doi: 10.1111/j.1346-8138.1977.tb00994.x. J Dermatol. 1977. PMID: 15461355 Review.
-
Structure, chemistry, and biosynthesis of the melanins.Fortschr Chem Org Naturst. 1974;31(0):521-82. doi: 10.1007/978-3-7091-7094-6_9. Fortschr Chem Org Naturst. 1974. PMID: 4372136 Review. No abstract available.
Cited by
-
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.Neurotox Res. 2003;5(3):165-76. doi: 10.1007/BF03033137. Neurotox Res. 2003. PMID: 12835121 Review.
-
Neuroprotective effects of 3α-acetoxyeudesma-1,4(15),11(13)-trien-12,6α-olide against dopamine-induced apoptosis in the human neuroblastoma SH-SY5Y cell line.Neurochem Res. 2011 Nov;36(11):1991-2001. doi: 10.1007/s11064-011-0523-1. Epub 2011 Jun 18. Neurochem Res. 2011. PMID: 21688047
-
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.PLoS One. 2013 Jun 12;8(6):e65983. doi: 10.1371/journal.pone.0065983. Print 2013. PLoS One. 2013. PMID: 23776585 Free PMC article.
-
Possible genotoxicity of melanin synthesis intermediates: tyrosinase reaction products interact with DNA in vitro.Mol Gen Genet. 1984;193(3):395-9. doi: 10.1007/BF00382074. Mol Gen Genet. 1984. PMID: 6423931
-
Approaches to prevent dopamine quinone-induced neurotoxicity.Neurochem Res. 2009 Apr;34(4):698-706. doi: 10.1007/s11064-008-9843-1. Epub 2008 Sep 4. Neurochem Res. 2009. PMID: 18770028 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
