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. 1983 May;303(5912):23-6.
doi: 10.1038/303023a0.

Chance, necessity and antibody gene dynamics

Chance, necessity and antibody gene dynamics

C Coleclough. Nature. 1983 May.

Abstract

Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whereas the exclusion of other loci from expression is a necessity imposed by the physiology of lymphocyte development.

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