Chance, necessity and antibody gene dynamics
- PMID: 6405281
- DOI: 10.1038/303023a0
Chance, necessity and antibody gene dynamics
Abstract
Early in their development B lymphocytes commit themselves to the expression of only one immunoglobulin light-chain gene and only one heavy-chain gene out of the large numbers of available loci. Here I shall present the view that the initial selection of loci for expression is made by chance, whereas the exclusion of other loci from expression is a necessity imposed by the physiology of lymphocyte development.
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