Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jan 1;209(1):229-33.
doi: 10.1042/bj2090229.

The inhibition of class C beta-lactamases by boronic acids

T Beesley, N Gascoyne, V Knott-Hunziker, S Petursson, S G Waley, B Jaurin, T Grundström

The inhibition of class C beta-lactamases by boronic acids

T Beesley et al. Biochem J. .

Abstract

Aromatic boronic acids are reversible inhibitors of the recently classified class C beta-lactamases. The boronic acids studied include ortho-, meta- and para-methyl-, -hydroxymethyl- and -formyl-phenylboronic acid. The beta-lactamases were chromosomally-encoded enzymes, one from Pseudomonas aeruginosa, and the other specified by the ampC gene of Escherichia coli. The inhibition may be correlated with our finding that these beta-lactamases are serine enzymes, i.e. their function entails the hydroxy group of a serine residue acting as a nucleophile.

PubMed Disclaimer

References

    1. J Antibiot (Tokyo). 1980 Nov;33(11):1262-9 - PubMed
    1. Biochemistry. 1981 May 12;20(10):2726-31 - PubMed
    1. J Gen Microbiol. 1982 Jan;128(1):155-9 - PubMed
    1. Biochem J. 1982 Mar 1;201(3):621-7 - PubMed
    1. Biochem J. 1982 Sep 1;205(3):631-3 - PubMed

Publication types

MeSH terms