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Clinical Trial
. 1983;79(4):304-7.
doi: 10.1007/BF00433406.

Effects of a single oral dose of 3-cyano-imipramine on serotonin uptake and content of platelets in healthy volunteers

M Kenny, T J Lenehan, R Lambe, A Darragh, I Brick, L M Omer
Clinical Trial

Effects of a single oral dose of 3-cyano-imipramine on serotonin uptake and content of platelets in healthy volunteers

M Kenny et al. Psychopharmacology (Berl). 1983.

Abstract

Changes in platelet serotonin uptake and content were investigated following administration of a single oral dose of 3-cyano-imipramine to healthy volunteers. The uptake of 3H-serotonin by platelets harvested from these subjects was almost completely inhibited 4 h after dose administration. This inhibition continued for at least 24 h. Plasma taken from the subjects inhibited the uptake of 3H-serotonin by platelets isolated from non-treated subjects. A small but significant reduction in platelet serotonin content was observed 3.75 h after dosing and was still evident after 24 h.

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References

    1. Br J Pharmacol Chemother. 1968 Jan;32(1):1-16 - PubMed
    1. Acta Pharmacol Toxicol (Copenh). 1979 Apr;44(4):289-95 - PubMed
    1. Br J Pharmacol. 1978 Feb;62(2):219-26 - PubMed
    1. Arch Gen Psychiatry. 1977 May;34(5):509-16 - PubMed
    1. Psychopharmacology (Berl). 1981;74(1):1-3 - PubMed

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