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. 1983 Jul 1;221(4605):63-5.
doi: 10.1126/science.6407112.

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A

G H Reem, L A Cook, J Vilcek

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A

G H Reem et al. Science. .

Abstract

Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.

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