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. 1983;69(2):141-7.
doi: 10.1007/BF00926950.

Parasitological and immunological aspects of Trypanosoma cruzi infection in nude rats

A M Rodriguez, D Afchain, F Santoro, H Bazin, A Capron

Parasitological and immunological aspects of Trypanosoma cruzi infection in nude rats

A M Rodriguez et al. Z Parasitenkd. 1983.

Abstract

The role of the thymus on immunity of rats against Trypanosoma cruzi infection was investigated in vivo. The athymic (nu/nu) rats were shown to be significantly more susceptible to the acute phase of the infection than the control nu/+ rats, as measured by increased parasitemia and mortality. Specific anti-T. cruzi antibodies, complement, IgM and IgG2a serum levels were determined. The results would indicate the essential role of antibodies in immunity to acute Chagas' disease through T-dependent immune response.

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