[Apolipoproteins A-1 and B of the blood plasma and apolipoproteins A-1 of 2 high-density lipoprotein subclasses in ischemic heart disease patients with various lipoprotein spectra]

Abstract

Apolipoproteins (apo A-1 and apo B) were measured by rocket immunoelectrophoresis in 53 patients 40-59 years of age with coronary heart disease. Patients with hyperlipoproteinemia and low HDL cholesterol level as well as those with normal lipid levels were compared with age-matched healthy controls. Apo A-1 blood plasma level reduction was found in the former group. The reduction is shown to be due to the decrease of apo A-1 composing HDL3 in type IIa and IIb hyperlipoproteinemia and in normal lipoprotein level. HDL2 apo A-1 reduction is also observed in type IV hyperlipoproteinemia. The rise of apo B level was noted in the blood plasma of patients with coronary heart disease, the changes being mainly connected with the increase in the number of apo B-containing particles. It is shown, that patients with coronary heart disease have an elevated apo B/apo A-1 ratio as compared to the control group, with its value exceeding 1 whatever the lipoprotein level. Changes in the quantitative composition of plasma apolipoproteins are considered to be a factor, ensuring prevalence of cholesterol flow to peripheral tissues over its acceptance and escape.