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. 1983 Jun 4;286(6380):1773-5.
doi: 10.1136/bmj.286.6380.1773.

Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies

A W Ritchie, I Oswald, H S Micklem, J E Boyd, R A Elton, E Jazwinska, K James

Circadian variation of lymphocyte subpopulations: a study with monoclonal antibodies

A W Ritchie et al. Br Med J (Clin Res Ed). .

Abstract

Use of monoclonal antibodies to identify subpopulations of circulating lymphocytes in healthy adults showed pronounced circadian variations in total T cells, the two major T cell subsets, and HLA-DR+ lymphocytes. When the results for the T cell subsets were expressed as a ratio (helper:suppressor) no significant rhythmic variation was observed. Lymphocytes bearing a surface antigen identified by the HNK-1 antibody (a population containing the natural killer and antibody dependent killer activity) did not show significant rhythmic variation. There was an inverse relation between plasma cortisol concentration and numbers of T and B cells. These observations have therapeutic implications and should be considered in the course of immunological monitoring.

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