Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Mar 15;210(3):783-7.
doi: 10.1042/bj2100783.

Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats

M Bollen, L Hue, W Stalmans

Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats

M Bollen et al. Biochem J. .

Abstract

The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phosphorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1515-9 - PubMed
    1. J Biol Chem. 1970 Feb 25;245(4):903-5 - PubMed
    1. Diabetes. 1970 Dec;19(12):916-23 - PubMed
    1. Am J Physiol. 1971 Feb;220(2):499-506 - PubMed
    1. Biochim Biophys Acta. 1972 Sep 15;279(2):245-59 - PubMed

Publication types