doi: 10.1016/0006-8993(83)90810-7.
Facilitation of neocortical kindling by depletion of forebrain noradrenaline
- PMID: 6409356
- DOI: 10.1016/0006-8993(83)90810-7
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Facilitation of neocortical kindling by depletion of forebrain noradrenaline
Brain Res.
.
Abstract
The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline significantly facilitated the rate of development of cortico-generalized seizures.
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