Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Jun 27;270(1):174-7.
doi: 10.1016/0006-8993(83)90810-7.

Facilitation of neocortical kindling by depletion of forebrain noradrenaline

I M Altman, M E Corcoran

Facilitation of neocortical kindling by depletion of forebrain noradrenaline

I M Altman et al. Brain Res. .

Abstract

The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline significantly facilitated the rate of development of cortico-generalized seizures.

PubMed Disclaimer

Publication types

LinkOut - more resources