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. 1983 May;18(5):465-72.
doi: 10.1111/j.1365-2265.1983.tb02876.x.

Testicular damage after radioactive iodine (I-131) therapy for thyroid cancer

D J Handelsman, J R Turtle

Testicular damage after radioactive iodine (I-131) therapy for thyroid cancer

D J Handelsman et al. Clin Endocrinol (Oxf). 1983 May.

Abstract

Testicular damage was evaluated in twelve men by determination of sperm counts, serum FSH, LH, and testosterone up to 3 1/2 years after treatment with radioactive iodine (131I) therapy for thyroid cancer. Dose-dependent spermatogenic damage with elevation of serum FSH was evident. Full recovery in one and partial recovery in another patient was documented during 2 1/2 years of follow-up. Serial study in two patients documented a small but significant effect of 50 mCi 131I on serum FSH levels and clinically important effects appear to be restricted to men having multiple doses totalling over 100 mCi.

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