Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets
- PMID: 6411067
- PMCID: PMC1152064
- DOI: 10.1042/bj2120433
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets
Abstract
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets as indicated by [32P]phosphatidate accumulation in platelets pre-labelled with [32P]Pi, and by [3H]phosphatidate accumulation and [3H]phosphatidylinositol loss in platelets pre-labelled with [3H]arachidonate. These effects of platelet-activating factor are direct and are independent of the production and/or release of endogenous platelet agonists such as ADP, 5-hydroxytryptamine and thromboxane A2.
Similar articles
-
Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets.J Biol Chem. 1982 Jul 10;257(13):7314-7. J Biol Chem. 1982. PMID: 7045103
-
Enhanced incorporation of exogenous arachidonic acid into phosphatidylinositol and other phospholipids during the early stages of thrombin-induced aggregation in gerbil platelets.Lipids. 1983 Dec;18(12):859-62. doi: 10.1007/BF02534562. Lipids. 1983. PMID: 6420635
-
Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium.Biochem J. 1984 May 1;219(3):833-42. doi: 10.1042/bj2190833. Biochem J. 1984. PMID: 6234886 Free PMC article.
-
Regulation of platelet phospholipid metabolism.Adv Exp Med Biol. 1985;192:281-91. doi: 10.1007/978-1-4615-9442-0_20. Adv Exp Med Biol. 1985. PMID: 3010669 Review. No abstract available.
-
Phospholipid metabolism and cell stimulus activation coupling in platelets and other blood cells.Surv Synth Pathol Res. 1984;3(6):457-76. doi: 10.1159/000156949. Surv Synth Pathol Res. 1984. PMID: 6100134 Review. No abstract available.
Cited by
-
[Relation between post-thrombotic syndrome, ADP-induced thrombocyte aggregation and intrathrombocyte calcium content].Klin Wochenschr. 1989 Dec 4;67(23):1194-8. doi: 10.1007/BF01716206. Klin Wochenschr. 1989. PMID: 2558255 German.
-
Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP.Biochem J. 1985 Nov 15;232(1):267-71. doi: 10.1042/bj2320267. Biochem J. 1985. PMID: 3002327 Free PMC article.
-
Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes.Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):354-8. doi: 10.1007/BF00168850. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2969081
-
Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets.Biochem J. 1986 Feb 15;234(1):67-73. doi: 10.1042/bj2340067. Biochem J. 1986. PMID: 3010956 Free PMC article.
-
Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin.Agents Actions. 1986 Mar;17(5-6):506-11. doi: 10.1007/BF01965522. Agents Actions. 1986. PMID: 3706054
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous