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. 1983 May 15;212(2):433-7.
doi: 10.1042/bj2120433.

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets

D E MacIntyre, W K Pollock

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets

D E MacIntyre et al. Biochem J. .

Abstract

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets as indicated by [32P]phosphatidate accumulation in platelets pre-labelled with [32P]Pi, and by [3H]phosphatidate accumulation and [3H]phosphatidylinositol loss in platelets pre-labelled with [3H]arachidonate. These effects of platelet-activating factor are direct and are independent of the production and/or release of endogenous platelet agonists such as ADP, 5-hydroxytryptamine and thromboxane A2.

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