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. 1983 Sep;67(9):805-10.

Pharmacokinetics of mitomycin C in patients receiving the drug alone or in combination

G A van Hazel, M Scott, J Rubin, C G Moertel, R T Eagan, M J O'Connell, J S Kovach
  • PMID: 6411337

Pharmacokinetics of mitomycin C in patients receiving the drug alone or in combination

G A van Hazel et al. Cancer Treat Rep. 1983 Sep.

Abstract

We have characterized plasma pharmacokinetics in 30 patients receiving mitomycin C (mitomycin) in doses ranging from 6 to 20 mg/m2 by iv bolus injection, either alone or in combination with other chemotherapeutic drugs. Plasma elimination of the drug was described by a two-compartment model in all but three cases, giving mean values for alpha-half-life of 8.2 mins, beta-half-life of 51.8 mins, and total body clearance of 332.9 ml/min/m2. The mean urinary excretion was 8.1% of the total dose administered. We did not detect alterations in pharmacologic parameters related to liver dysfunction, dose of mitomycin, and concomitant administration of other cytotoxic drugs.

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