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. 1983 Sep 15;39(9):1050-1.
doi: 10.1007/BF01989800.

The effect of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of X-irradiated rats

S R Stepanović, J Nikolić

The effect of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of X-irradiated rats

S R Stepanović et al. Experientia. .

Abstract

The effect of a mixture of l-DOPA and benserazide on the amount of dopamine in the corpus striatum of rats irradiated with 850 R of X-rays was investigated. The amount of dopamine in the corpus striatum was measured fluorimetrically at various times after irradiation. It was found that i.p. administration of l-DOPA and benserazide 1,2 and 5 days after irradiation produces significant replenishment of dopamine in the striatum, thus indicating that precursor uptake and metabolism, and probably amine storage, remained unaltered after irradiation.

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