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. 1983;18(2):111-6.
doi: 10.1007/BF00368538.

Recombination between kappa chain genetic markers and the Lyt-3 locus

D M Gibson, S J Maclean, M Cherry

Recombination between kappa chain genetic markers and the Lyt-3 locus

D M Gibson et al. Immunogenetics. 1983.

Abstract

Recombination has been detected for the first time between chromosome 6 loci controlling kappa chain expression in normal mouse serum immunoglobulin and the Lyt-3 locus. The recombination event occurred at the 26th or 27th backcross generation during the derivation of the Lyt-2a, Lyt-3a-congenic line B6.PL(85NS). The line is now homozygous for the Lyt-2a, Lyt-3a allele(s) at N30F13 and homozygous animals express the Igk-Ef1b allele derived from C57BL/6. The frequency of recombination has been estimated to be 0.30% based on the present results and previous studies in which no recombination was detected. The results rule out the hypothesis that the Lyt-3 locus itself controls the light chain phenotype observed in normal serum immunoglobulin.

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