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. 1983 Sep;155(3):1324-32.
doi: 10.1128/jb.155.3.1324-1332.1983.

Sequence-specific DNA modification in Neisseria gonorrhoeae

C Korch, P Hagblom, S Normark

Sequence-specific DNA modification in Neisseria gonorrhoeae

C Korch et al. J Bacteriol. 1983 Sep.

Abstract

Neisseria gonorrhoeae 82409/55(pJD1) is postulated to possess six DNA sequence-specific cytosine methyltransferases and one DNA sequence-specific N6-adenine methyltransferase. From the DNA sequencing of the plasmid pJD1 (manuscript in preparation) by a modification of the Maxam and Gilbert chemical cleavage procedure, the cytosine methylation specificities were demonstrated. Five of these methylating enzymes and their respective specificities are M . NgoI (formula; see text) does not methylate the cytosine of its recognition sequence, in agreement with a detected adenine modification. A biological implication of these different DNA methylating activities is discussed.

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References

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