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. 1983 Oct;4(10):1247-51.
doi: 10.1093/carcin/4.10.1247.

Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes

S A Wrighton, J K Pai, G C Mueller

Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes

S A Wrighton et al. Carcinogenesis. 1983 Oct.

Abstract

Treatment of bovine lymphocytes with phorbol esters activates an oxygen-dependent system for the formation of a class of arachidonic acid metabolites which appears distinct from prostaglandins, prostacyclins, thromboxanes and leukotrienes. A full activation of the system is achieved within minutes by 10(-7) M 12-O-tetradecanoylphorbol-13-acetate. This activation can be largely prevented by the lipoxygenase inhibitors, 5,8,11,14-eicosatetraynoic acid and nordihydroguaiaretic acid.

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