Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci
- PMID: 6413409
- PMCID: PMC264532
- DOI: 10.1128/iai.42.1.122-125.1983
Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci
Abstract
Interferon-gamma affected the expression of the products of the immunoassociated antigen complex by a differential modulation of DR- and DC-locus-controlled molecules. In melanoma M14 cells treated with interferon-gamma, levels of DR molecules were increased two- to threefold, whereas levels of DC molecules were increased six- to sevenfold. Similar effects were induced on the two allelic products of each locus.
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