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. 1983 Aug;2(4):316-20.
doi: 10.1007/BF02019460.

Effect of alkaline glutaraldehyde on hepatitis B virus antigens

K Adler-Storthz, L M Sehulster, G R Dreesman, F B Hollinger, J L Melnick

Effect of alkaline glutaraldehyde on hepatitis B virus antigens

K Adler-Storthz et al. Eur J Clin Microbiol. 1983 Aug.

Abstract

The potential of alkaline 2% glutaraldehyde solutions, with and without surface active agents, to alter the antigenicity of hepatitis B virus (HBV) was analyzed and compared to the antigenic alternation capacities of 0.525% sodium hypochlorite and 2.02% formaldehyde solutions. After treatment of a hepatitis B surface antigen-positive plasma at room temperature for 10 min, there was a 51-67% reduction in surface antigen level and a 90-94% decrease in hepatitis B core antigenicity. Glutaraldehyde is proposed as an alternative to the more noxious hypochlorite and formaldehyde solutions for disinfection of HBV-contaminated articles.

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