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. 1983 Nov 1;158(5):1739-44.
doi: 10.1084/jem.158.5.1739.

Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes

M Brownlee, S Pongor, A Cerami

Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes

M Brownlee et al. J Exp Med. .

Abstract

The chronic tissue damage associated with long-term diabetes mellitus may arise in part from in situ immune complex formation by accumulated immunoglobulins and/or antigens bound to long-lived structural proteins that have undergone excessive nonenzymatic glycosylation. In this report, we have tested this hypothesis using nonenzymatically glycosylated collagen. Binding of both albumin and IgG averaged four times the amount bound to unmodified collagen. Both albumin and IgG (anti-BSA) bound to nonenzymatically glycosylated collagen retained their ability to form immune complexes in situ with free antibody and antigen.

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References

    1. Adv Food Res. 1965;14:167-283 - PubMed
    1. Adv Food Res. 1963;12:1-52 - PubMed
    1. Anal Biochem. 1976 May 7;72:248-54 - PubMed
    1. Diabetes. 1976 Aug;25(8):701-8 - PubMed
    1. Diabetes. 1976;25(2 SUPPL):850-7 - PubMed

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