Second-trimester abortion by extra-amniotic instillation of Rivanol combined with intravenous administration of oxytocin or prostaglandin F2 alpha

Abstract

Induction of second-trimester abortion was studied by administration of the acridine derivative Rivanol in combination with an i.v. drip infusion of oxytocin or prostaglandin F2 alpha (PG2 alpha), alone or in combination. It was found that an early onset of the i.v. infusion was of major importance for the outcome. Administration of oxytocin in immediate connection with the Rivanol instillation proved more favorable than administration of PGF2 alpha) or a combined oxytocin PGF2 alpha drip, taking into consideration the induction-abortion time as related to the side effects. A lag phase between the instillation of Rivanol and the start of i.v. infusion such as has earlier been frequently recommended seemed to be of no specific advantage, but caused both a prolonged induction-abortion time and an increased incidence of infection.

PIP: Induction of 2nd trimester abortion was studied by administration of the acridine derivative Rivanol in combination with an intravenous (iv) drip infusion of oxytocin or prostaglandin (PGF2alpha), alone or in combination. It was found that an early onset of the iv infusion was of major importance for the outcome. Administration of oxytocin in immediate connection with the Rivanol instillation proved more favorable than PGF2alpha administration or a combined oxytocin/PGF2alpha drip, taking into consideration the induction-abortion time as related to side effects. A lag phase between Rivanol instillation and the start of the iv infusion such as has earlier been frequently recommended seemed to be of no specific advantage, but caused both a prolonged induction-abortion time and an increased incidence of infection.