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. 1983 Sep;24(3):429-31.
doi: 10.1128/AAC.24.3.429.

In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis

In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis

M H Cynamon et al. Antimicrob Agents Chemother. 1983 Sep.

Abstract

The comparative in vitro activity of amoxicillin alone and in combination with clavulanic acid against 15 isolates of Mycobacterium tuberculosis was evaluated by broth dilution susceptibility testing. Amoxicillin inhibited 4 of 15 isolates at 8 micrograms/ml or less but was not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid was bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 micrograms/ml or less and a clavulanic acid concentration of 2 micrograms/ml or less.

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References

    1. Antimicrob Agents Chemother. 1982 Dec;22(6):1079-81 - PubMed
    1. Tubercle. 1980 Dec;61(4):213-9 - PubMed

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