Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Dec 1;158(6):1868-80.
doi: 10.1084/jem.158.6.1868.

Tolerance for self IG at the level of the Ly1+ T cell

E K Bikoff

Tolerance for self IG at the level of the Ly1+ T cell

E K Bikoff. J Exp Med. .

Abstract

Experiments presented in this report demonstrate that specificity of the Ly1+ T cell proliferative response to NP-modified Ig is controlled by Igh-C-linked genes. In addition, we describe the mechanism whereby Igh-C-encoded molecules influence Ly1+ T cell activity. We show that Igh-C-linked control of T cell responses to NP-modified Ig is a secondary consequence of naturally acquired tolerance for self Ig. Unresponsiveness to self Ig is not due to a defect expressed functionally at the level of the antigen-presenting cell, nor is it associated with active suppression. These results suggest that tolerance for self Ig at the level of the Ly1+ T cell is due to functional deletion of Ly1+ T cell clones specific for self Ig. The possibility is considered that regulatory effects mediated by passively administered antibodies may in part be due to induction of Ly1+ T cell tolerance for self Ig.

PubMed Disclaimer

References

    1. Eur J Immunol. 1975 Oct;5(10):661-6 - PubMed
    1. J Immunol. 1983 Jul;131(1):103-8 - PubMed
    1. Eur J Immunol. 1973 Oct;3(10):645-9 - PubMed
    1. J Exp Med. 1974 Mar 1;139(3):712-20 - PubMed
    1. J Immunol. 1974 Dec;113(6):1876-82 - PubMed

Publication types