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. 1983;65(2):99-101.
doi: 10.1007/BF00286642.

Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia

H Joenje, A B Oostra

Effect of oxygen tension on chromosomal aberrations in Fanconi anaemia

H Joenje et al. Hum Genet. 1983.

Abstract

Blood samples from four healthy individuals and from seven Fanconi anaemia (FA) patients were cultured at oxygen tensions ranging from 3% to 45% O2. Cultures were harvested at 72 h and scored for chromosomal aberrations. In the majority of FA patients the aberration frequency showed a tendency to increase as a function of oxygen tension over the culture, whereas the aberration frequency in healthy individuals was not affected. However, the response in FA cultures was variable among patients and in individual cases when assayed on different occasions. A much stronger effect of oxygen tension was observed when the FA blood samples had been treated with mitomycin C (0.25 microgram/ml, 30 min) before culture initiation.

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References

    1. Cancer Res. 1973 Aug;33(8):1829-36 - PubMed
    1. Biochim Biophys Acta. 1982 Dec 31;699(3):217-25 - PubMed
    1. Biochim Biophys Acta. 1979 Jan 26;561(1):99-109 - PubMed
    1. Hum Genet. 1982;62(4):327-32 - PubMed
    1. Exp Cell Res. 1960 Sep;20:613-6 - PubMed

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