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. 1978 May;53(1):131-6.
doi: 10.1530/jrf.0.0530131.

Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption

I E Lawrence Jr, H W Burden, T M Louis

Effect of abdominal vagotomy of the pregnant rat on LH and progesterone concentrations and fetal resorption

I E Lawrence Jr et al. J Reprod Fertil. 1978 May.

Abstract

Abdominal vagotomy on Day 8 of pregnancy in rats decreased the number of live fetuses at Day 16 and increased the number of resorbing fetuses. The activity of delta5-3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the corpus luteum and interstitial gland, LH and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PGF levels were not affected. We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.

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