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. 1984 Jan 14;288(6411):96-9.
doi: 10.1136/bmj.288.6411.96.

Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene

N I Jowett, L G Williams, G A Hitman, D J Galton

Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene

N I Jowett et al. Br Med J (Clin Res Ed). .

Abstract

A polymorphic DNA sequence was studied on the 5' flanking region of the human insulin gene in relation to diabetic lipaemia. The genotype frequencies in a control population (n = 52) were homozygous L 6%, heterozygous 54%, and homozygous S 40%. Corresponding genotype frequencies in a hypertriglyceridaemic group (n = 74) were 18%, 66%, and 16% (p less than 0.01; chi 2 test). When the hypertriglyceridaemic patients were divided on the basis of glucose tolerance the corresponding genotype frequencies in the diabetic subgroup (n = 23) were 39%, 52%, and 9% compared with 0%, 74%, and 26% in the non-diabetics (n = 34) (p less than 0.001; chi 2 test). These findings suggest that the homozygous L genotype may confer susceptibility to diabetic hypertriglyceridaemia.

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References

    1. Ann Hum Genet. 1955 Jun;19(4):251-3 - PubMed
    1. J Mol Biol. 1977 Jun 15;113(1):237-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1245-9 - PubMed
    1. Diabetologia. 1979 May;16(5):313-7 - PubMed
    1. Lancet. 1982 Dec 11;2(8311):1291-3 - PubMed

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